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We publish the most up-to-date information for a medicine in accordance with its licence history. The complete physique clearance of sildenafil is 41 L/h with a resultant terminal part half- lifetime of 3-5 h. The N-desmethyl metabolite is additional metabolised, with a terminal half-life of roughly 4 h. There was no impact on sperm motility or morphology after single 100 mg oral doses of sildenafil in healthy volunteers (see part four.6).

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